● Autophagy.（IF=13.391）.Ruolin Li, et.al.（2021）. Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model.［首都医科大学 SNCA过表达质粒 自噬、帕金森病］

● NATURE COMMUNICATIONS.（IF=17.694）. Xiaolong Tang, et.al.（2021）. Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis .［浙江大学 FLAG-AMPKα1 & FLAG-SKP2 & FLAG-AKT1过表达质粒 恶性肿瘤］

● NATURE COMMUNICATIONS.（IF=17.694）. Lijuan Zhang，et.al.（2021）. Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage Polarization .［天津医科大学Myc-IkBa & HA-UB K48 巨噬细胞］

● J Immunother Cancer.（IF=12.469）. Rui Qin，et.al.（2021）. Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation ［复旦大学 NFATc过表达质粒 色氨酸免疫激活］

● Genome Biology.（IF=17.906）. Xujia Wu，et.al.（2021）.A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity［中山大学第一附属医院 PTCH1 & Gli1过表达质粒 胶质母细胞瘤］

●  Neuro-Oncology. （IF=13.029）. Kaikai Yi，et.al.（2021）.PTRF/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2 . [天津医科大学 PTRF过表达质粒 胶质母细胞瘤]

●  EMBO Molecular Medicine.（IF=14.260）. Xujia Wu，et.al.（2021）.Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation. [中国科学院NANOG过表达质粒 肺癌]

●  Cell Death & Disease.(IF=6.304) .Hao et al. (2020) .Dual regulation of p53 by the ribosome maturation factor SBDS. ［复旦大学 SBDS过表达质粒 肺癌和结肠癌］

●  Cell Death & Disease.(IF=6.304) .Fu et al. (2020) .Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression. ［香港浸会大学 TLR4过表达质粒 黑色素瘤］

●  Biochemical Pharmacology.(IF=4.96) .Li et al. (2020) .Downregulation of OCTN2 by Cytokines Plays an Important Role in the Progression of Inflammatory Bowel Disease. ［浙江大学 SLC22A5过表达质粒 HT29&FHC cells 炎症性肠病IBD］

●  Cancer Letters.(IF=7.36) .Liu et al. (2020) .MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma. ［中南大学湘雅医院 MYH9过表达质粒 肺癌细胞］

●  Cancer Letters.(IF=7.36) .Luo et al. (2019) .DMBX1 promotes tumor proliferation and regulates cell cycle progression via repressing OTX2-mediated transcription of p21 in lung adenocarcinoma cell. ［江苏省肿瘤医院 肺癌细胞］

●  Redox Biology.(IF=9.986) .Tian et al. (2019) .aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1.［华中科技大学同济医学院附属同济医院 PRKCI & KEAP1表达质粒 胆囊癌］

●  Phytomedicine. (IF 7.9). Pan et.al. (2023). Synergistic neuroprotective effects of two natural medicinal plants against CORT-induced nerve cell injury by correcting neurotransmitter deficits and inflammation imbalance. [山东中医药大学中医学院 miRNA-144-3p过表达和干扰质粒 神经]

●  Pharmacological Research.(IF=5.893) .Huang et al. (2020) .MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/β-catenin signaling by targeting XIAP and ZEB2.［华中科技大学同济医学院附属同济医院 mir377过表达质粒 结直肠癌］

●  PPAR Research.(IF=2.953) .Xu et al. (2019) .Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p.［复旦大学附属中山医院 mir590过表达质粒 内皮损伤］

●  Theranostics.(IF=8.579) .Song et al. (2019) .Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction.［华中科技大学同济医学院附属同济医院mir21过表达质粒 急性心肌梗死MI］

●  Experimental Hematology & Oncology (IF=9.4).Huang S, et.al. (2024). Combined inhibition of MET and VEGF enhances therapeutic efficacy of EGFR TKIs in EGFR-mutant non-small cell lung cancer  with concomitant aberrant MET activation.［华中科技大学同济医学院附属同济医院 荧光素酶报告基因质粒构建服务  EGFR突变型非小细胞肺癌］

●  Annals of the Rheumatic Diseases. (IF 27.4). Zhao et.al. (2023). SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy. [郑州大学第一附属医院，sgRNA质粒]

●  J Immunother Cancer.（IF=12.469）. Qi- Hua Peng，et.al.（2021）.CMTM6 and PD- L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer. ［中山大学 pEnter- CMTM6- Flag过表达质粒 直肠癌］

●  Cell Death Dis. (IF=6.304). Ma, et al. (2020). circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.［江苏省肿瘤医院 pAV-circRNA 5615 结直肠癌］

●  Toxicol. Appl. Pharmacol. (IF=3.347). Ge & Tu, et al. (2020). MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1.［上海市第一人民医院 & 上海交通上海交通大学医学院 pcDNA3.1-FLAG-CCAR1 放射性直肠损伤］

●  Cell Death Dis. (IF=6.304). Zhang, et al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.［上海交通大学医学院 pADM-circHIPK3-GFP 肺纤维化］

●  Int J Med Sci. (IF=2.523). Wang, et al. (2019). LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1.［南方医科大学 pCMV-SNHG6 结直肠癌］

●  EBioMedicine. (IF=5.736). Jiang, et al. (2019). Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling.［广州医科大学 HA-tagged full-length p65 and the truncated p65 fragments plasmids 乳腺癌］

●  Aging (Albany NY). (IF=4.831). Li, et al. (2019). Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation.［南方医科大学南方医院 pcDNA3.1-FLAG-p21 WT & pcDNA3.1-FLAG-p21 KR & pcDNA3.1-FLAG-p21 KQ 心肌细胞增殖］

●  R Soc Open Sci. (IF=2.647). Liu, et al. (2018). Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS.［浙江大学医学院附属第一医院pSH-U6-miR-143-5p-gRNA(or miR-143-3p-gRNA/miR-145-5p-gRNA/miR145-3p-gRNA)-CMV-SpCas9-P2A-Puro 人表皮角质细胞HEKs 尖锐湿疣(CA)］

● International Journal of Oral Science（IF 14.9）.Zhang DX.（2024）. Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK.［山东大学，AdV5-CMV-GFP-LC3,AdV5-GFP-RFP-LC3，CAL 27细胞（人舌鳞癌细胞） MOI 100，口腔鳞状细胞癌.］

● Biol Psychiatry. (IF=12.095). Zhao D, et al. (2019). RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.［厦门大学 Ad-PSD-95 & Ad-control GFP 阿尔兹海默症］

● J Clin Endocrinol Metab. (IF=5.399). Li M, et al. (2019). The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.［山东大学 Ad-HMGA2 多囊卵巢综合征］

● Int J Cardiol. (IF=3.229). Wu B, et al. (2018). Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.［湖北医药学院 Ad-Meox1 血管重塑］

● Life Sci. (IF=6.304). He M, et al. (2018). In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer.［北京大学 Ad-FUZ & Ad-NC 非小细胞肺癌］

● Cell Death Dis. (IF=6.304). Sun S, et al. (2017). Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.［华中科技大学同济医学院附属同济医院 Ad-PDK4 肿瘤代谢］

● Molecular Medicine Reports. (IF=2.1). Zhang S, et al. (2017). PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells. ［南方医科大学南方医院 Ad-PAR1 热应激诱导HUVEC凋亡］

● Hepatology. (IF=14.679). Xiang D, et al. (2017). Shp2 promotes liver cancer stem cell expansion by augmenting β-atenin signaling and predicts chemotherapeutic response of patients.［东方肝胆外科医院 AdShp2 and AdGFP 肝癌］

● Cancer Letters. (IF=7.36). Wang Z , et al . (2017). CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrinβ1/FAK/AKT signaling.［中山大学附属第一医院 Ad-CXCL1胃癌］

● Gene. (IF=2.984). Zhang J W, et al. (2017). Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function.［北京大学第一医院 Ad-CMTM5-v1& Ad-mock 冠心病］

● Cell Death Dis. (IF=6.304). Zheng Y, et al. (2017). Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. ［上海交通大学医学院 & 中国科学院上海生命科学研究院 Ad-Atg5 缺血性心脏病］

● Oncoimmunology. (IF=5.869). Wang H, et al. (2016). Interactions between colon cancer cells and tumor-infiltrated macrophages depending on cancer cell-derived colony stimulating factor 1. ［山东齐鲁医院 Ad-hCSF1瘤内注射 结肠癌］

● Basic Res Cardiol. (IF=11.981). Sun Z, et al. (2016). Cross-talk between macrophages and atrial myocytes in atrial fibrillation.［浙江大学医学院附属第一医院 Ad-QKI 心房纤颤］

● Mol Carcinog. (IF=3.825). Wang J, et al. (2016). Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice.［复旦大学 Ad-TFPI & Ad-GFP 肿瘤］

● Frontiers in Immunology. (IF 8.786). Huang et.al. (2023). FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-kB mediated endothelial oxidative stress. [华中科技大学同济医学院附属同济医院 Ad-FGL2-miRNA 血脑屏障]

● Hypertension. (IF=9.897).Junni Wang，et.al.（2021）.MicroRNA-87 4-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury. [浙江大学第一附属医院 Ad-miR-874-3p 肾纤维化]

● Stem Cells Int. (IF=3.869). Li X, et al. (2019). MicroRNA-150 Modulates Adipogenic Differentiation of Adipose-Derived Stem Cells by Targeting Notch3.［中国医科大学 Ad-miR-150 脂肪源性干细胞］

● Oncotarget. (IF=5.168). Tian S, et al. (2017). miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.［贵州医科大学附属医院 Ad-miR-138-5p & Ad-miR-NC 胰腺癌细胞自噬］

● Journal of Hazardous Materials (IF=12.2). Zhang Y, et.al. (2025). F-53B disrupts energy metabolism by inhibiting the V-ATPase-AMPK axis in neuronal cells.［石河子大学医学院 Ad-V-ATPase B2  神经毒性］

● Journal of Advanced Research（IF=11.4）. Sun K, et.al. (2024). TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway.［华中科技大学同济医学院附属同济医院&武汉市第四医院 Ad-TRPM2、Ad-GFP  骨关节炎］

● Cancer Immunology Research (IF 8.1). Xiang X, et.al. (2024). Blocking CX3CR1+ Tumor-associated Macrophages Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma.［杭州医学院 Ad-CX3CR1、Ad-NC 肝细胞癌］

● Signal Transduction and Targeted Therapy (IF 40.8). Fang L, et.al. (2024). Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity.［北京大学/华南理工大学/西南医科大学Ad-SMAD4、Ad-MYCBP2、Ad-NC 肥胖］

● Cell Death & Disease (IF 8.1). Peng et.al. (2024). Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α. [上海长征医院谢渭芬、张鑫团队 Ad-HNF1α(K197R)肝癌]

●Cell & Bioscience（IF 7.9）.Lei ZY.（2024）. Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation.［中山大学附属第三医院，Ad-CMV-Med1，尾静脉注射,3.6×10^9 PFU,急性肝衰竭］

● Cell Communication and Signaling ( IF 8.2 ). Ma et.al. (2024). Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis. [西安交通大学第一附属医院丁小明团队 内胚层分化]

● Redox Biology (IF 11.4). Shao et.al. (2024). FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease. [华中科技大学同济医学院附属协和医院董念国、李飞研究团队联合南京医科大学第一附属医院研究团队 钙化性主动脉瓣疾病]

● Molecular Metabolism (IF 8.1).Li J, et.al. (2024). Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.［武汉大学人民医院 Ad-DNER、Ad-DNER (Tyr⁶⁷⁷ to Ala)、Ad-HA 肝糖异生］

●Journal of Nanobiotechnology (IF 10.2).Ye L, et.al. (2024). Modulation of alveolar macrophage and mitochondrial fitness by medicinal plantderived nanovesicles to mitigate acute lung injury and viral pneumonia.［浙江树人学院转化医学研究院 Ad-ACE2  急性肺损伤和病毒性肺炎］

●Nature Communications（IF 16.6）.Wang SJ.（2024）. Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity.［中山大学、广州医科大学附属第一医院，Ad5-GALNT3/T7，Ad5-EV，人肺腺癌细胞Calu-3，MOI 1000，新冠病毒防御机制］

●VIEW（IF 8.6）.Zhu JW.（2023）. The PES1/FOXM1 heterodimer suppresses TCF21 and ERβ expression in ovarian endometriosis.［北京大学第一医院，Ad-Pes1，Ad-vector，体内注射109pfu，子宫内膜异位症.］

●Acta Pharmaceutica Sinica B (IF 14.5). Rong et.al. (2024). Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis. [华西医院杜丹、夏庆团队，Ad- XDH，胰腺炎]

●Cell Metabolism（IF 29）.Dong YM.（2024）. A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.［华中科技大学附属同济医院，Ad-shRNA-Slc40a1（pAd-4 in 1 shRNA），骨髓源性巨噬细胞 MOI 200.骨质疏松］

● Advanced Science（IF 15.1）.Ding L.（2024）. Beta-Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5.［山东大学基础医学院，Ad-CMV-Gnas，Ad-CMV-Tipe1，MIN6细胞/Islets细胞，2型糖尿病.］

●Journal of Medical Virology (IF 12.7). Yu et.al. (2023). SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species. [华中科技大学同济医学院基础医学院，Ad5-S2NP]

●BMC Biology（IF 5.4）.You WJ.（2023）. GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.［浙江大学，Ad-Gadd45a，Ad-Ctrl.小鼠/猪皮下脂肪细胞.脂肪代谢］

●J Clin Invest，（IF 15.9）.Yang ZY.（2023）. Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress.［第四军医大学，Ad-CTCF、Ad-Ctrl，人脐静脉内皮细胞(HUVECs)，MOI 200，肿瘤血管］

●Metabolism，（IF 9.8）.Hu YT.（2023）. Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.［北京大学医学部基础医学院、北京大学人民医院，AAV8-FPR1、AAV8-GFP，尾静脉注射，肝脂肪代谢］

●Acta Pharmacologica Sinica（IF8.2）.Huang YM, et.al. (2023). Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation.［广州医科大学 Ad-hPar3L、Ad-GFP  动脉粥样硬化性心血管疾病］

●Journal of Translational Medicine (IF=7.4).Xiong W, et.al. (2023). UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.［华中科技大学同济医学院附属协和医院 Ad-UCP1 、Ad-Ctrl  肾间质纤维化］

●Free Radical Biology and Medicine. (IF 7.4). Zhang et.al. (2023). Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis. [第四军医大学基础医学院、第四军医大学西京医院，AAV和腺病毒过表达载体AAV9-cTNT-frataxin，Ad-Frataxin 心脏]

●JACC-Basic to Translational Science，（IF 9.531）. Zhu ZY.（2023）. Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis.［浙江大学医学院附属第二医院 Adv-shGDF-11，心肌细胞（CMs），MOI=200，心力衰竭］

●Journal of Molecular Medicine，（IF 5.606）. Shao SY.（2023）. Never in mitosis gene Arelated kinase6 deficiency deterioratesdiabetic cardiomyopathy via regulating heat shock protein 72.［郑州大学第一附属医院Ad-NEK6，MOI=50，心肌细胞，糖尿病心肌病］

●Signal Transduction and Targeted Therapy（IF 39.3）.Chunsik Lee. et.al.（2023）. VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway［中山大学中山眼科中心，瑞典卡罗林斯卡研究院联合复旦大学附属眼耳鼻喉科医院Ad-FGFR1 WT，Ad-FGFR1 Y463F, Ad-FGFR1 Y585F，Ad-FGFR1 Y653F人脐静脉内皮细胞-HUVECs，MOI=10，血管］

●iScience （IF 6.107）.Li YJ.（2023）.Phosphodiesterase type 10A inhibitor attenuates lung 1 fibrosis by targeting myofibroblast activation［浙江大学医学院附属邵逸夫医院 pADM-PDE10A，人胚肺成纤维细胞（HFL-1），肺部纤维化］

●ISCIENCE. (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells. [中山大学附属第一医院 AAV和腺病毒过表达载体 胰腺]

●Journal of Translational Medicine. (IF=8.44). Zhang RN, et.al. (2023). The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy.［湖北医药学院 Ad-NFATc1、Ad-NFATc2、Ad-shNFATc3、Ad-shNFATc4、Ad-Null 腓骨肌萎缩症］

●J CELL COMMUN SIGNAL.（IF=5.908）.Liu X, et.al. (2023). Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF‑α/STAT3/autophagy axis.［武汉协和医院 Ad-Sam68 钙化主动脉瓣疾病］

●Journal of Nutritional Biochemistry.（IF=6.117）Liu J, et.al. (2023). Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.［华中科技大学同济医学院公共卫生学院 Ad-Frataxin 酒精性肝病］

●Acta Pharmacologica Sinica. (IF 7.169) Guo et.al. (2023). JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit. [山东第一医科大学 JMJD6 腺病毒过表达载体 心肌肥厚]

●Journal of Neuroinflammation. (IF 9.587) Qian Xia et.al. (2022). Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1. [华中科技大学同济医院 SIRT5腺病毒过表达和干扰载体 神经炎症]

●Ecotoxicology and Environmental Safety. (IF 7.129) Jingjing Zhang et.al. (2023). The inhibition of TRPML1 TFEB leads to lysosomal biogenesis disorder contributes to developmental fluoride neurotoxicity. [新疆石河子大学 TFEB腺病毒过表达载体 氟神经毒性]

●ARTERIOSCL THROM VAS（IF=10.514）.Shu Liu，et.al.（2022）.Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein ［中国医学科学院阜外医 AdV-TPRG1-AS1和AdVMYH9 动脉粥样硬化］

●Journal of Cachexia, Sarcopenia and Muscle.（IF=12.063）.You W , et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.［浙江大学动物科学学院 Ad-GADD45A 肌内脂肪沉积］

● Free Radical Biology and Medicine. (IF 8.101). Liu Y, et.al. (2022). LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway.［郑州大学第一附属医院 Ad-LRRK2 & Ad-LRRK2 D1994A & Ad-NC 心肌梗死］

● Journal of Molecular and Cellular Cardiology.（IF=5.763）.Wang S, et.al. (2022). Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair.［中山大学中山医学院&南方医科大学珠江医院 Ad-SIRT6 & Ad-GFP 血管钙化］

● Molecular Neurobiology. (IF=5.682). Zhou B, et.al. (2022). FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.［南昌大学第一附属医院 Ad-FUS & Ad-FUS-K510Q  肌萎缩侧索硬化症］

● Cell and Bioscience. (IF=9.584). Mao M, et.al. (2022). SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury. ［华中科技大学附属同济医院&郑州大学附属中心医院 Ad-SENP6 & Ad-vector 脑中风］

● Arterioscler Thromb Vasc Biol.（IF=10.514）. Ren X, et.al. (2022). Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein. ［中国医学科学院阜外医院 Ad-TPRG1-AS1 & Ad-MYH9 动脉粥样硬化性心血管］

● Pharmacol Res.(IF=10.334). Zhu S, et al. (2022). The miR-145-MMP1 axis is a critical regulator for imiquimod-induced cancer stemness and chemoresistance. ［吉林大学第一医院转化医学研究所 Ad-miR-145 & Ad-control 肿瘤干性］

● Acta Biomaterialia.（IF=10.633）. Wang F, et.al. (2022). Adipose-derived stem cells with miR-150-5p inhibition laden in hydroxyapatite/tricalcium phosphate ceramic powders promote osteogenesis via regulating Notch3 and activating FAK/ERK and RhoA. ［中国医科大学 Ad-miR-150-5p & Ad-NC 骨质疏松症］

● Molecular Cancer. (IF=41.444).Lei Liu，et.al.（2021）.KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1. ［山东大学Ad-KDM6A & Ad-GFP 膀胱癌］

● Signal Transduction and Targeted Therapy.（IF=38.104）.Suowen Xu, et.al.（2021）.The zinc fifinger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction.［中国科技大学 Ad-KLF2 & Ad-GFP 内皮功能障碍］

● Redox Biology .(IF=10.787).Yaqian Huang，et.al.（2021）.Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling. [北京大学第一医院 Ad-AAT1 血管重塑]

● Theranostics.（IF=38.104）.Yan Jiang, et.al.（2021）. Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis. [复旦大学Ad-Jmjd3 & Ad-Jmjd3-mut肝纤维化]

● Nat Commun. (IF=17.694). Liu R, et.al. (2022). MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake. ［山东第一医科大学附属眼科研究所Ad-GFP＆Ad-CMV-Glut2＆Ad-insulin 1-miR-21  胰腺β细胞］

● Cell Metab. (IF=27.287). Zhou N, et.al. (2022). Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. ［北京大学&山一大附属省立医院 Ad-PPARd &Ad-OTUD3&Ad-control 糖脂代谢］

● Genes & Diseases. (IF=7.103). Luo J, et.al. (2022). PLSCR1 Promotes Apoptosis and Clearance of Retinal Ganglion Cells in Glaucoma Pathogenesis. ［中山大学Ad-PLSCR1&Ad-control 青光眼］

●  J Cell Physiol.  (IF=5.546) . Wang M, et al. (2021) . Lack of Mof reduces acute liver injury by enhancingtranscriptional activation of Igf1. [过表达/干扰 急性肝损伤]

●  Front Cell Dev Biol.  (IF=5.201) . Gu J, et al. (2021) . CFTR Deficiency Affects Glucose Homeostasis via Regulating GLUT4 Plasma Membrane Transportation. [过表达 成肌细胞]

●  Front Immunol.  (IF=5.085) . Wu L, et al. (2021) . EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice. [过表达 狼疮肾炎]

●  [4]Oxid Med Cell Longev.  (IF=5.076) . Gao Y, et al. (2021) .Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress. [过表达 心肌]

●  J Cell Mol Med.  (IF=4.486) . Lei W，et al. (2021) . MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway. [过表达 心肌]

●  J Biol Chem.  (IF=4.238) . Zhang Z，et al. (2021) . The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. [过表达/干扰 肝脏]

●  J Anim Sci Biotechnol.  (IF=4.167) . Liu J, et al. (2021) . Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses. [过表达 脂肪细胞]

●  Aging. (IF=4.831) .Chen Y, et al. (2020). Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats[自噬双标 术后认知功能障碍].

● Elife Tool. (IF=7.08). Wu L, et al. (2019). PARIS, an optogenetic method for functionally mapping gap junctions.［北京大学 Ad-CMV-pHluorinCAAX 缝隙连接探针］

● Cell Death Dis. (IF=6.304). Su Y, et al. (2019). MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis.［中山大学眼科中心 & 中山大学中山医学院 Ad-TAB2 & Ad-NEMO HUVECs 动脉粥样硬化］

● EBioMedicine. (IF=5.736). Wang K, et al. (2019). TGF-beta1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.［温州医科大学附属台州医院 Ad-p65 & Ad-EV 肝纤维化］

● Arthritis Res Ther. (IF=4.103). Zeng J, et al. (2019). Interferon-alpha exacerbates neuropsychiatric phenotypes in lupus-prone mice.［上海交通大学医学院附属仁济医院 Adv-IFN-α & Adv-ctrl系统性红斑狼疮］

● Oncogene. (IF=7.971). Yu M, et al. (2018). Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility. ［北京大学深圳研究生院 Ad-AXL 胶质母细胞瘤］

● Cell Death Discov. (IF=4.114). Zhang SQ, et al. (2018). Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3beta activity.［香港浸会大学 Ad-GSK3β (S9A) 神经干细胞NSCs］

● Int J Mol Med. (IF=3.098). Zhang L, et al. (2018). Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-kappaB pathway.［武汉大学人民医院张杰团队 Ad-Lefty-1 肾脏炎］

● Redox Biol. (IF=9.986). Jin Q, et al. (2018). DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.［中国人民解放军总医院 Ad-DUSP1 & Ad-ctrl 心脏缺血再灌注损伤］

● Cell Physiol Biochem. (IF=5.5). Wang Y, et al. (2018). Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. ［浙江大学医学院附属第二医院Ad- mCherry-GFP-LC3 心脏重塑］

● Brain,Behavior,and Immunity. (IF=6.633). Zhou Y.T, et al. (2017). Interleukin-1βimpedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion.［浙江大学 Ad-IL-1R1-RFP & Ad-RFP 皮层下缺血性血管性痴呆SIVD］

● J Pharmacol Sci. (IF=2.835). Li J, et al. (2016). PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy.［中山大学 Ad-PKCζ & Ad-GFP心肌肥厚］

● Arthritis Rheumatol. (IF=9.586). Han X, et al. (2016). MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells.［上海交通大学医学院 Ad-IFNα5 狼疮肾炎］

● Sci Rep. (IF=3.998). Zhang H, et al. (2016). Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor. entific Reports.［北京大学第一医院 Ad-AAT1 3T3-L1 cell 脂肪组织慢性炎症］

● Mol Cell Biol. (IF=3.611). Wu C, et al. (2016). Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity.［南方科技大学 Ad-Cre RNA聚合酶I转录活性］

● Cell Death Discovery (IF=6.1). Wei X, et.al. (2024). Tert promotes cardiac regenerative repair after MI through  alleviating ROS-induced DNA damage response in cardiomyocyte.［南方医科大学南方医院 ADV-shTert、ADV-sh-NC  心肌再生］

● Molecular Metabolism (IF 8.1).Li J, et.al. (2024). Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.［武汉大学人民医院 Ad-U6-shDNER、Ad-U6-shRNA control 肝糖异生］

● ACS Applied Materials & Interfaces（IF 9.5）.Yu KX.（2023）. Cancer-Erythrocyte Membrane-Mimicking Fe3O4 Nanoparticles and DHJS for Ferroptosis/ Immunotherapy Synergism in Tumors.［华中科技大学同济医学院附属同济医院、湖北科技学院、武汉大学中南医院，Ad-shRNA-Nrf2，Ad-shRNA-con.HOS细胞（人骨肉瘤细胞）MOI 50.骨肉瘤］

● Pharmacol Res.（IF=10.334）. Dong Y, et.al. (2022). Blocking the cytohesin-2/ARF1 axis by SecinH3 ameliorates osteoclast-induced bone loss via attenuating JNK-mediated IRE1 endoribonuclease activity. ［华中科技大学附属同济医院 Ad-4in1-shCytohesin-1 ；Ad-4in1-shCytohesin-2；Ad-4in1-shCytohesin-3；Ad-4in1-shNC 骨质疏松］

● Mol Ther. (IF=12.910). Zheng H, et al. (2022) . CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. ［南方医科大学 Ad-shcircSamd4 & Ad-NC 心肌梗死］

● Biomedicine & Pharmacotherapy.（IF=7.419）. Hong Q, et.al. (2022). Trimethylamine-N-oxide (TMAO) promotes balloon injury-induced neointimal hyperplasia via upregulating Beclin1 and impairing autophagic flux .［南方医科大学珠江医院 Ad-shBeclin1 & Ad-shNC 血管重塑］

● Journal of Cellular and Molecular Medicine. (IF=4.486). Wang, et al. (2020). Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. ［华中科技大学同济医学院同济医院骨科 murine PFKFB3 Adenoviruses-4 in 1 shRNA-GFP 骨髓源性巨噬细胞BMMs MOI=50 破骨细胞相关疾病］

● EBioMedicine. (IF=5.736. Li, et al. (2019). Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway.［南方医科大学南方医院 AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP 人脐静脉内皮细胞HUVECs MOI=100 新血管形成］

● Bone. (IF=4.147). Zhao, et al. (2018). YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.［华中科技大学同济医学院同济医院骨科 murine YAP1 Adenoviruses-4 in 1 shRNA-GFP 骨髓源性巨噬细胞BMMs & RAW264.7 cells 破骨细胞生成］

● Cardiovascular Research. (IF=8.168. Li, et al. (2018). Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.［南方医科大学南方医院 AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP 心肌细胞CMs MOI=100 & 大鼠心肌注射 心脏再生］

● Br J Pharmacol. (IF=6.304). Ma Z.G, et al. (2016). Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKalpha signalling pathway. ［武汉大学人民医院 Ad-shAMPKα2 心肌肥厚］

● Clin Sci . (IF=5.223). Ling Y, et al. (2016). Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux. ［南方医科大学珠江医院 Ad-sh-Beclin1&Ad-NC 心肌缺血再灌注损伤］

● Int J Biol Sci. (IF=4.858). Ma Z G, et al. (2016). Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKalpha Signalling Pathway. ［武汉大学人民医院 Ad-shAMPKα2 心肌肥厚］

● Nat Commun. (IF=12.121). Fu R, et al. (2020). Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. ［中国药科大学Ad-βGal & Ad-Cre 骨质疏松］

● Cancer Sci. (IF=4.966). Wang X, et al. (2020). Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo. ［南方科技大学Ad-LacZ & Ad-Cre 肺癌］

● Int. J. Mol. Sci. (IF=4.556). Xu, et al. (2020). Effective MSTN Gene Knockout by AdV-Delivered CRISPR/Cas9 in Postnatal Chick Leg Muscle.［上海交通大学 AdV-CRISPR system(pAdM-U6-gRNA1-U6-gRNA2-CMV-spCas9) 鸡胚成纤维细胞DF-1 MOI=1000 & 鸡肌肉注射 鸡骨骼肌的生长和发育］

● ACS Nano.（IF=18.027）.ChunHua-Zhao，et.al.（2023）.Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.［中山大学肿瘤防治中心、东海大学LV-EF1a-luciferase-CMV-GFP-P2A-Puro三阴性乳腺癌］

● Nature Communications (IF 14.7). chen et.al. (2024). The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression. [南方医科大学李学农团队 结直肠癌]

● Journal of Advanced Research（IF 11.4）.Huang XG.（2024）. Exploitation of enhanced prime editing for blocking aberrant angiogenesis.［深圳市眼科医院 , NILV-LV5、NILV-LV6、NILVs-PE6x-VEGFR2、NILVs-PE6x-lacZ，视网膜血管生成］

● International Journal of Biological Sciences (IF 8.2).Lu F, et.al. (2024). Hypoxic tumor-derived exosomal miR-4488 induces macrophage M2 polarization to promote liver metastasis of pancreatic neuroendocrine neoplasm through RTN3/FABP5 mediated fatty acid oxidation.［南京医科大学第一附属医院 miR-4488过表达及干扰慢病毒载体 胰腺神经内分泌肿瘤］

● Cancer Letters（IF 9.1）.Meng HY.（2024）. YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification.［南京医科大学第一附属医院，LV-CMV-YBX1、LV-CMV-shYBX1，卵巢癌］

●Clin. Transl. Med.（IF 7.9）.Guan X.（2024）. Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer.［哈尔滨医科大学附属肿瘤医院，PLent-Puro-CMV-NLRP3慢病毒载体，结直肠癌］

● Oncogene (IF 8.0). Wei et.al. (2024). The splicing factor WBP11 mediates MCM7 intron retention to promote the malignant progression of ovarian cancer. [山东大学齐鲁医院宋坤/李英伟团队 卵巢癌]

●Cell Death & Disease (IF 9.0).Yao Y, et.al. (2024). Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes.［山东中医药大学附属医院 Lenti-PDK1 、Lenti-GFP 糖尿病神经病变］

Cancer Immunology Research (IF 10.1). Wang et.al. (2023). Combination anti-PD-1 and electroacupuncture induces a potent anti-tumor immune response in microsatellite-stable colorectal cancer. [哈尔滨医科大学郑桐森团队，pLent-Puro-CMV–luciferase，结直肠癌]

● Journal of Experimental & Clinical Cancer Research (IF 11.3). Xie et.al. (2023). Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation. [南京医科大学附属第一医院，LV-LBP、LV-shLBP、LV-TLR4、LV-NC、LV-GFP，胃癌肝转移]

● Cell Death & Bioactive Materials (IF 18.9). Wu et.al. (2024). Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair. [中南大学湘雅医院、中国科学院遗传与发育生物学研究所联合北京药理学与毒理学研究所，Lv-TrkC，脊髓损伤修复]

● Cellular and Molecular Life Sciences. (IF 8.0). Song et.al. (2023). FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell–crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-κB signaling. [武汉大学人民医院、武汉大学技术科学研究所，AAV干扰载体、慢病毒过表达和干扰载体 肾脏]

● Cellular & Molecular Biology Letters，（IF 8.3）. Kuang Xiangqin.（2023）. Peptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NF-κB activation via disrupting multiple-site ubiquitination of NEMO.［广州医科大学附属肿瘤医院，Lv-PI16，Lv-shRNA-PI16，膀胱癌-BLCA细胞］

● Cell Death Discovery. (IF 7.0). Zhang et.al. (2023). Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis. [南京医科大学第一附属医院 AAV慢病毒过表达载体 AAV9-RCAN1.4 LV-RCAN1.4、LV-YY1  肾脏]

● Death and Disease，（IF 9.685）. Xie XF.（2023）. BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.［中国医学科学院北京协和医学院，LV-BACH1、LV-shBACH1，食管鳞状细胞癌］

● Cancer Immunology, Immunotherapy，（IF 6.63）. Wu PT.（2023）. LILRB2-containing small extracellular vesicles from glioblastoma promote tumor progression by promoting the formation and expansion of myeloidderived suppressor cells［苏州大学第二附属医院&上海华山医院LV-pirb & LV-pirb-RFP & LV-nc 小鼠胶质母细胞瘤GL261细胞系 MOI=50， 胶质母细胞瘤］

● The Journal of Nutritional Biochemistry.（IF=5.6）.Chen H, et.al. (2023). Autophagy and exosomes coordinately mediate quercetin's protective effects on alcoholic liver disease.［华中科技大学 Lv-CYP2E1 酒精性肝病］

● Journal of Translational Medicine（IF=8.440）Bo Sun，et.al.（2023）.AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway.［湖南省人民医院 AFAP1L1/VAV2/ITGA5过表达以及干扰慢病毒 胃癌］

● Cell Death Discovery. (IF 7.0) Wang et.al. (2023). NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress. [湖北医药学院 NSUN2慢病毒过表达载体 心脏]

● Journal of Experimental & Clinical Cancer Research. (IF 12.658) Huang et.al. (2023). Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling. [中山大学孙逸仙纪念医院 LCN2慢病毒过表达和敲除载体 口腔鳞状细胞癌]

● Molecular Cell. (IF 19.328) Jinzhou Huang et.al. (2023). SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology. [同济大学医学院 53BP1慢病毒干扰过表达载体 DNA修复]

● CNS Neurosci Ther.（IF=7.035）. Miao Y，et.al. (2023). Anti-cancer effect of targeting fibroblast activation protein alpha in glioblastoma through remodeling macrophage phenotype and suppressing tumor progression.［首都医科大学附属北京天坛医院 Lv-FAP 胶质母细胞瘤］

●Oncogene.（IF=8.756）. Chen H，et.al. (2022). Extracellular vesicles-transferred SBSN drives glioma aggressiveness by activating NF-κB via ANXA1-dependent ubiquitination of NEMO.［广州医科大学 Lv-SBSN 胶质瘤］

●Cell Reports.（IF=9.995）. Li H, et.al. (2022). β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-a β-hydroxybutyrylation.［四川大学华西医院 pLenti-EF1α-CMV-CaMKII-α-Flag-GFP-2A-Puro；pLenti-EF1α-CMV-mutant CaMKII-α-Flag-GFP-2A-Puro 药物成瘾］

● Cancer Letters.（IF=9.756）.Wang Y , et.al. (2022). NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity.［浙江大学医学院 Lv-NNMT&Lv-NNMTY20 乳腺癌］

● J Exp Clin Cancer Res.（IF=12.658）. Qiu S, et.al. (2022). Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis.［南京医科大学第一附属医院 Lv-miR-519a-3p ；Lv-miR-519a-3p-shRNA 胃癌肝转移］

● Cancer Lett. (IF=9.756). Wang Y, et.al. (2022). NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity. ［浙江大学医学院 pLenti-Pur-NNMT & pLenti-Pur-NNMT-Y20 & pLenti-Pur 乳腺癌］

● EBioMedicine. (IF=11.205). Xiao RW, et.al. (2022). Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication. ［中山大学附属肿瘤医院 Lv-POLN 鼻咽癌］

● J Exp Clin Cancer Res. (IF=12.658). Qiu S, et.al. (2022). Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis. ［南京第一附属医院 Lv-miR-519a-3p&Lv-miR-519a-3p-shRNA 胃癌］

● Am J Med Sci. (IF=3.462). Luo R. (2022). CircRNA circ-MYBL2 absorbs precursor miR-92b in the nucleus to suppress its role in enhancing gastric cancer cell proliferation. ［成都人民医院 LV-circ-MYBL2 胃癌］

● Cancer Letters. (IF=9.756).Peng Nan, et.al.(2021).Tumor-stroma TGF-β1-THBS2 feedback circuit drives pancreatic ductal adenocarcinoma progression via integrin αvβ3/CD36-mediated activation of the MAPK pathway.［中国医学科学院北京协和医学院Lv-shPCK2-1 & Lv-shPCK2-2胰腺导管腺癌］

● Cancer Letters. (IF=9.756). Xiaofeng Li，et.al.(2021).SETD8 stabilized by USP17 epigenetically activates SREBP1 pathway to drive lipogenesis and oncogenesis of ccRCC.［山东大学齐鲁医院pLent-U6- SETD8-GFP-Puro 肾细胞癌］

● J Immunother Cancer.（IF=12.469）. Chao Liu,et.al.(2021).Blocking IL- 17A enhances tumor response to anti- PD- 1 immunotherapy in microsatellite stable colorectal cancer [哈尔滨医科大学肿瘤医院pLent-Puro- CMV- miR-15b-5p & AAV- miR- 15b- 5p 直肠癌 ]

● Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma.［华中科技大学同济医学院附属协和医院pLent-SNHG12-GFP-Puro & pLent-shSNHG12-GFP-Puro 肾癌细胞RCC cells］

● Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression.［香港浸会大学 lentivirus-CA-TLR4, fused with Myc and Flag tags 黑色素瘤细胞A375 cells］

● Cell Death & Disease. (IF=6.304). Wang, et al. (2019). LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.［华中科技大学同济医学院附属协和医院 pLent-LXRα-GFP-Puro & pLent-GFP-sh-LXRα-Puro 肾癌细胞RCC cells］

● Biochemical and Biophysical Research Communications. (IF=2.985). Zhu, et al. (2019). MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3.［北京大学第三医院 lent-miR-506 套细胞淋巴瘤细胞］

● Molecular Cancer. (IF=15.302). Tan, et al. (2019). PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.［中山大学 pLent-Puro-GFP-piR-36712 人乳腺癌细胞MCF7和ZR75-1］

● Advanced Science. (IF=15.84). Lai, et al. (2018). A Modular Assembly of Spinal Cord–Like Tissue Allows T argeted Tissue Repair in the T ransected Spinal Cord. ［中山大学 pLent-EF1a-NT-3-Flag-CMV-GFP-P2A-Puro & pLent-EF1a-TrkC-Flag-CMV-GFP-P2A-Puro & pLent-EF1a-CNTF-Flag-CMV-GFP-P2A-Puro 神经干细胞NSCs & 少突胶质前体细胞OPCs 脊髓损伤］

● Theranostics. (IF=8.579). Mai, et al. (2018). PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma.［中山大学 pLent-Puro-GFP-piR-54265 人结肠癌细胞HCT116和LoVo］

● Toxicology Letters. (IF= 3.569). Yan, et al. (2018). Inhibitory Effect of PXR on Ammonia-induced Hepatocyte Autophagy via P53.［福建医科大学附属协和医院 pLent-EF1a-PXR-CMV-GFP & pLent-U6-shPXR-GFP-Puro 人肝细胞HL-7702 和人肝癌细胞 BEL-7404 肝自噬］

● Journal of Advanced Research (IF 11.4) Jia et.al. (2025). Comprehensive multi-omics analyses exposes a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition. [浙江大学医学院附属第一医院郑树森院士、宋朋红 人源激酶gRNA慢病毒文库 肝细胞癌]

● Journal of Advanced Research (IF 11.4) Xie et.al. (2024). Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity. [南方医科大学南方医院丁轶、方媛、詹益芝团队 Lv-shATM、Lv-shNC 结直肠癌]

● Free Radical Biology and Medicine (IF=7.1). Ji R, et.al. (2024). Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis.［武汉大学人民医院 Lv-sh-CD44、Lv-sh-SLC7A11、Lv-sh-NC  多囊卵巢综合征］

● Cell Communication and Signaling (IF 8.4).Li H, et.al. (2024). VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage.［哈尔滨医科大学附属肿瘤医院 Lv-shVDR 胰腺癌］

● Cell Death and Differentiation (IF 12.4).Du Y, et.al. (2024). APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy. ［南京师范大学 Lv-shAPE1 肝细胞癌］

● Pharmacological Research (IF 9.3). Peng et.al. (2024). Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor. [华中科技大学同济医学院附属同济医院李锋、关邯峰团队联合重庆大学生物工程学院冯茜，骨]

● Cell Death & Disease (IF 9.0).Sun Y, et.al. (2023). METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway.［山东第一医科大学附属肿瘤医院 Lv-METTL3-gRNA、Lv-METTL3-shRNA、Lv-YTHDF1-shRNA 结直肠癌］

● BMC Biology（IF 5.4）.You WJ.（2023）. GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.［浙江大学，Lv-shGadd45a，Lv-shCtrl.小鼠/猪皮下脂肪细胞.脂肪代谢］

● British Journal of Cancer，（IF 8.8）.Zhang SJ .（2023）. Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28.［山东大学第二医院&山东大学齐鲁医院，靶向FOSL2和KRAS基因的shRNA干扰慢病毒，胰腺导管腺癌］

● Cellular and Molecular Life Sciences. (IF 8.0). Song et.al. (2023). FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell–crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-κB signaling. [武汉大学人民医院、武汉大学技术科学研究所，AAV干扰载体、慢病毒过表达和干扰载体 肾脏]

● Cell Death and Differentiation. (IF 12.067). Liang et.al. (2023). The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway. [浙江大学医学院第一附属医院慢病毒干扰载体 pLent-shRNA-p62 肝脏]

● Metabolism Clinical and Experimental. (IF 13.934) Zhang et.al. (2022). ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease. [四川大学华西医院 pLent-RFP-shRNA-ABCA1 慢病毒干扰载体 糖尿病]

● Cell Death & Differentiation.（IF=12.067）.Zhang G , et.al. (2023). Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.［四川大学华西第二医院、武汉大学 pLent-shCT55 雄性不育］

● Journal of Agricultural and Food Chemistry.（IF=5.895）.Di-Ran，et.al.（2023）.Reactive Oxygen Species Control Osteoblast Apoptosis through SIRT1/PGC-1α/P53Lys382 Signaling, Mediating the Onset of Cd-Induced Osteoporosis.［扬州大学Lv-SIRT1-shRNA干扰慢病毒 骨质疏松］

● Angiogenesis.(IF=10.658 ).Weisi-Lu，et.al.（2022）.PDGFD switches on stem cell endothelial commitment.［中山大学中山眼科医院 PDGFD过表达和敲低（4in1 shRNA）慢病毒载体 血管病干细胞治疗］

● Journal of Cachexia, Sarcopenia and Muscle.（IF=12.063）.You W , et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.［浙江大学动物科学学院 Lv-GADD45A-shRNA 肌内脂肪沉积］

● Neurosci Bull.（IF=5.271）.Wang T, et.al. (2022). The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.［北京大学第六医院 LV-CRH-shRNA 睡眠障碍］

● Cancer Letters. (IF=9.756).Zongpan Jing, et.al.(2021).Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy.[北京协和医科大学肿瘤医院 Lv-PCK2-shRNA 肝癌]

● Molecular Therapy: Nucleic Acids. (IF=10.183).Yu Zhang，et.al.(2021). Suppression of RNA editing by miR-17 inhibits the stemness of melanoma stem cells. [浙江大学 Lv-DOCK2-shRNA & psPAX & PMD2.G质粒 黑色素瘤干细胞]

● Cell Death and Disease. (IF=9.685).Xiaofang Chen，et.al.(2021). TCP1 increases drug resistance in acute myeloid leukemia by suppressing autophagy via activating AKT/mTOR signaling. [福建医科大学附属协和医院 Lv-TCP1-shRNA 急性髓系白血病]

● Cell Death and Disease. (IF=9.685). Bo Sun，et.al.(2021). Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation. [中南大学湘雅医院 Lv-PP2Ac-shRNA & Lv-PDCD10-shRNA 肝癌]

● Cancer Letters. (IF=9.756).Fang-Jing Zhong, et.al.(2021).STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFβ signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma. [中南大学湘雅医院 STMN2 3保1-shRNA 肝癌]

● Bioact Mater. (IF=14.593). Liu Y, et.al. (2021). DNA aptamer S11e recognizes fibrosarcoma and acts as a tumor suppressor. ［湖南大学 Diablo/SMAC 3保1 shRNA慢病毒 纤维肉瘤］

● Cell Death & Disease. (IF=6.304). You, et al. (2020). GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice.［浙江大学 Lenti-sh-Gadd45a BAT cell & Ad-Gadd45a SVF细胞 肥胖］

● Journal of Neuroinflammation. (IF=5.793). Zeng, et al. (2019). Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury.［北京大学第三医院 LV-SNCA-shRNA 脊髓损伤］

● Cell Discovery. (IF=6.255). Liao, et al. (2019). USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia.［广州医科大学 pLent-4in1shRNA(For USP10/SKP2)-GFP & pLent-EF1a-FH-CMV-GFP containing SKP2-CDS, SKP2 (S72A) CML cells MOI=10 慢性粒细胞白血病CML］

● International Journal of Biological Sciences. (IF=4.858). Zheng, et al. (2019). Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.［郑州大学附属第一医院lentiviruses-shAMPKa1 心肌注射 糖尿病性心肌病］

● Oncogene. (IF=7.971). Liao, et al. (2018). Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination.{广州医科大学 pLent-4in1shRNA[For human USP14 (NM-005151)]-GFP 人乳腺癌细胞 MOI=10 雄激素受体阳性乳腺癌}

● J Mol Cell Cardiol. (IF= 4.133). Li, et al. (2017). TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C.［山东大学千佛山医院 4in1shRNA慢病毒lenti-RNAi-TCONS_00075467 原代心肌细胞 心房颤动AF的电重构］

● International Journal of Molecular Sciences (IF=6.208). Yang D, et.al. (2023). Pharmacological T argeting of Bcl-2 Induces Caspase 3-Mediated  Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer.［重庆文理学院 Lv-mCherry-GFP-LC3B 结直肠癌］

● Nature Communications (IF 14.7) Wei et.al. (2025). A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo. [北京大学药学院王晶教授联合中国科学院遗传与发育生物学研究所武照伐研究员及北京大学生命科学学院李毓龙教授团队 AAV2/9-hSyn-HypnoS AAV2/9-hSyn-HypnoS-mut AAV5-GfaABC1D-HypnoS AAV5-GfaABC1D-HypnoS-mut 神经]

Nature Communications (IF 14.7) Chen et.al. (2024). Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance. [上海市第六人民医院胡承、张燚 AAV-EF1α-DIO-Fam172a-EGFP 神经]

● Journal of Advanced Research. (IF=11.4) Zhao et.al. (2024). Hippocampal dipeptidyl peptidase 9 bidirectionally regulates memory associated with synaptic plasticity. [中科院昆明动物研究所周启心团队 AAV2/9-hSyn-DPP9-FLAG、AAV2/9-hSyn-GFP-WPRA、AAV2/9-CMV-Cas13d-FLAG-U6-2x gRNA DPP9、AAV2/9-CMV-Cas13d-FLAG-U6-2x gRNA NC 神经]

● Acta Neuropathologica Communications. (IF=6.2) Lian et.al. (2024). Protein phosphatase 2Cm-regulated branched-chain amino acid catabolic defect in dorsal root ganglion neurons drives pain sensitization. [四川大学华西医院吕沛林、李涛团队 AAV9–hsyn-cre 神经]

● Advanced Science(IF=14.3). Zhu Y, et.al. (2024). Adenosine-Dependent Arousal Induced by Astrocytes in a Brainstem Circuit. ［浙江大学脑科学与脑医学学院  AAV2/5-GfaABC1D-hPMCA2w/b-mCherry、AAV2/5-GfaABC1D-mCherry、AAV2/9-hsyn-GRABAdo1.0、AAV2/9-hsyn-GRABAdo1.0mut、AAV2/9-hsyn-GRABATP1.0 、AAV2/5-GfaABC1D-ChrimsonR-mCherry  睡眠觉醒］

● Advanced Science (IF 14.3). Wang et.al. (2024). Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development. [中国科学院大学焦建伟团队联合四川大学华西医院陈蕾团队、郑州大学第一附属医院许予明团队 血管内皮，AAV.BI30-FDFT1]

● Nature（IF=50.5）. Pascal S. Kaeser et.al. (2024). Dopamine dynamics are dispensable for movement but promote reward responses.［哈佛医学院 AAV9-hSyn-GRABDA2m  多巴胺动力学］

● npj Parkinson's Disease (IF 6.7). Cao B et.al. (2024). PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease.［山东大学 AAV9-α-syn、AAV9-siTFE3、AAV9-siTFEB、AAV9-PDCD4、AAV9-Ctrl 帕金森病］

● Cell Reports (IF 7.5). Li et.al. (2024). Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation. [四川大学华西医院岑小波团队 AAV2/8-CaMKII-mutant PDHA1-Flag 神经]

● Journal of Neuroinflammation （IF 9.3）.Zhang WY.（2024）. Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.［山东第一医科大学附属济宁第一人民医院, AAV9-U6-sh-AKAP8L，AAV9-U6-sh-NC，糖尿病相关认知障碍］

● Nature Neuroscience (IF 21.2). Chen et.al. (2024). Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice. [北京脑科学与类脑研究所井淼团队 神经 ]

● Cancer Cell (IF 50.3). Zhong et.al. (2024). Distinct roles of TREM2 in central nervous system cancers and peripheral cancers. [中山大学附属第一医院张弩团队 北京大学白凡团队，AAV9-F4/80-TREM2-flag-p2A-GFP，胶质母细胞瘤]

● Environment International（IF 11.8）.Lin JH.（2024）. circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.［南京医科大学，AAV9-F4/80-miR30.shRNA-circADAMTS6，鼻滴 100 μL（5 × 10^11VP），每周1次，持续2周，肺气肿］

● Neuron，（IF 16.2）.Feng JS.（2024）. Monitoring norepinephrine release in vivo using next-generation GRABNE sensors.［北京大学，AAV9-hSyn-GRABNE2m/NE2h，AAV9-Ef1a-DIO-C1V1-YFP，AAV9-GRABNE1m ，AAV9-GRABNE2m，AAV9-GRABNE2h，AAV9-hSyn-NE2m，AAV9-hSyn-NEmut .李毓龙实验室新升级第二代去甲肾上腺素探针］

● Molecular Psychiatry，（IF 13.437）.Wang CS .（2023）. Targeting PDK2 rescues stress-induced impaired brain energy metabolism.［山东第一医科大学附属济宁市第一人民医院，AAV9-hSyn-sh-NC，AAV9-hSyn-sh-GR，AAV9-hSyn-sh-PDK2，脑立体定位注射，抑郁症］

● Nature Communications，（IF 16.6）.Zhan JB .（2023）. GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21.［浙江大学基础医学院与附属邵逸夫医院、、复旦大学脑科学转化研究院、深圳华大生命科学研究院，AAV9-CaMKIIα-Cre-EGFP、AAV9-CaMKIIα-EGFP，脑立体定位注射、双侧扣带回，神经元衰老］

● Current Biology（IF=9.2）. Xinli Xu et.al. (2024). Hypothalamic CRF neurons facilitate brain reward function.［中国科学院深圳先进技术研究院 AAV9-hSyn-DA4.4 奖励］

● Acta Pharmacologica Sinica（IF 8.2）.Cheng J.（2024）. Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice.［同济大学，AAV9-hSyn-TPH2-P2A-GFP，8.89×10^13 V.G/mL ；AAV9-hSyn-GFP，7.71×10^13 V.G/mL；立体定位注射，DRN区.1μL，1.11×10^9 V.G，0.2 μL /min］

● Cell Discovery (IF=33.5).Yang G et.al. (2024). TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons.［南京大学医学院模式动物研究所&郑州大学附属第一医院&南京鼓楼医院 AAV2/5-hSyn-DIO-GCaMP6s-P2A-nlsdTomato-hGH-pA、AAV2/5-CamKIIα-Cre-P2A-mCherry-WPRE-hGH-pA 渴觉］

● Developmental Cell (IF=11.8). Wang Y, et.al. (2023). BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development.［中国科学院动物研究所AAV9-F4/80-GFP-mir30shRNA (Bach1)、AAV9-F4/80-GFP-mir30shRNA (control) 脑发育］

● ISCIENCE（IF=6.107）. Xia Q, et.al. (2023). SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury.［华中科技大学同济医学院附属同济医院 AAV2/6-U6-DIO-scramble control-EGFP、AAV2/6-U6-DIO-SENP3/shRNA-EGFP 缺血性脑卒中］

● Science，（IF 56.7）. Li Yulong.（2023）. A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors.［北京大学, AAV9-hSyn-CRF1.0 ,AAV9-hSyn-CRFmut, AAV9-hSyn-CCK1.0,AAV9-hSyn-EGFP-CAAX，AAV9-hSyn-SST1.0，神经递质探针］

● Nature Methods，（IF 48）. Li Yulong.（2023）. Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo.［北京大学 ，AAV2/9-hSyn-gDA3m,AAV2/9-hSyn-gDA3h,AAV2/9-hSyn-gDA3mut,AAV2/9-hSyn-gDA2m,AAV2/9-hSyn-dLight1.3b,AAV2/9-hSyn-ACh3.0,AAV2/9-hSyn-eCB2.0,AAV2/9-hSyn-NE2m.多巴胺探针］

● JACC-Basic to Translational Science，（IF 9.531）. Zhu ZY.（2023）. Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis.［浙江大学医学院附属第二医院，AAV9-cTnT-Myc-GDF-11，心脏，尾静脉注射，心力衰竭］

● Molecular Neurobiology. (IF 5.68). Wang et.al. (2023). The circ_006573/miR‑376b‑3p Axis Advances Spinal Cord Functional Recovery after Injury by Modulating Vascular Regeneration. [上海交通大学医学院附属仁济医院 AAV干扰载体 AAV-circ_006573-shRNA 神经]

● ISCIENCE（IF 6.107）.Li Xiao.et.al.（2023）. Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection［香港城市大学 AAV-hSyn-CCK2.3 听觉皮层，立体定位注射，神经-皮层可塑性］

● BMC Biology. (IF=7.364). Wang Z, et.al. (2023). Neural ensembles in the murine medial prefrontal cortex process distinct information during visual perceptual learning.［中国科学技术大学 AAV9-CaMKlla-GCaMP6f、AAV2/9-CaMKIIa-hM4Di-mCherry、AAV2/9-CaMKIIa-mCherry视知觉学习］

● The FASEB Journal. (IF 5.834). Yang et.al. (2023). Netrin-1 attenuates cerebral ischemia/reperfusion injury by limiting mitochondrial ROS and Ca2+ levels via activation of AKT phosphorylation and mitochondrial m- AAA protease AFG3L2. [上海交通大学医学院 Ad-Netrin-1；Ad-Control；Ad-shNetrin-1；Ad-shControl AAV-Netrin-1；AAV-Control；AAV-U6-shNetrin-1；AAV-U6-shControl AAV腺病毒过表达和干扰载体 脑损伤]

● Phytomedicine. (IF 6.656) Ouyang et.al. (2023). Khellin as a selective monoamine oxidase B inhibitor ameliorated paclitaxel-induced peripheral neuropathy in mice. [南京中医药大学 AAV-MAOB-shRNA AAV干扰载体 神经]

● Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSSInduced DepressiveLike Behaviors［浙江大学医学院邵逸夫医院AAV-CMV-shLcn2 丘脑室旁核（PVT），双侧注射 抑郁样行为］

● Biomaterials. (IF 15.304) Lai et.al. (2023). Tail nerve electrical stimulation promoted the efficiency of transplanted spinal cordlike tissue as a neuronal relay to repair the motor function of rats with transected spinal cord injury. [中山医学院 CNTF NT3 TrkC AAV过表达载体 神经]

● iScience（IF=6.107）.Mahadi Hasan，et.al.（2023）.Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats.［香港城市大学 AAV8-GFAP-hM3D(Gq)-mCherry 认知缺陷］

● Translational Psychiatry（IF=7.989）.Ya-Xin Sun ，et.al.（2023）.The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits in male mice.［北京大学第六医院 AAV2/9-CaMKIIa-Cre-P2A-GFP & AAV2/9-CaMKIIa-GFP 认知障碍］

● Neurosci. Bull.(IF=5.271).SiYue-Qin，et.al.（2022）.REEP1 Preserves Motor Function in SOD1G93A Mice by Improving Mitochondrial Function via Interaction with NDUFA4.［山东大学基础医学院AAV1-hREEP1-Flag & AAV1-GFP 神经退行性疾病］

● Neuron. (IF 18.688) Yang et.al. (2023). Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. [约翰霍普金斯大学 Gabrd AAV敲除载体 神经]

● CELL MOL BIOL LETT. (IF 8.702) Zhonglin Cai et.al. (2022). ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity. [中国医学科学院北京协和医院 ALKBH5 AAV干扰载体 血睾屏障]

● Cell Reports.（IF=9.995）. Li H, et.al. (2022). β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-a β-hydroxybutyrylation.［四川大学华西医院 AAV2/9-CaMKII-α-EGFP-Flag；AAV2/9-mutant CaMKII-α-EGFP-Flag  药物成瘾］

● NEURAL REGENERATION RESEARCH.（IF=6.058）.Shu Liu，et.al.（2022）.Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage［南方医科大学珠江医院 AAV9-shRNA-NOX4 和AAV9-CON  脑出血治疗靶点］

● BMC biology.（IF=7.364）.Shu Liu，et.al.（2022）.Astrocytes in CA1 modulate schema establishment in the hippocampal-cortical neuron network.［香港城市大学AAV2/9-Ef1α-DIO-jGCaMp7s和AAV9-Syn-jGCaMp7s  CA1星形胶质细胞］

● Nat Biotechnol. （IF=68.164）.Qian T, et.al. (2023). A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments.［北京大学 AAV2/9-hSyn-OT1.0 ；AAV2/9-hSyn-OTmut；AAV2/9-hSyn-iGluSnFR (SF.iGluSnFR.A184V)；AAV2/9-CMV-BFP2-P2A-TeNT；AAV2/9-hSyn-DIO-PSD95-EGFP  催产素神经递质］

● Neuron（IF=18.688）.Tian F, et.al.(2022).Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells. ［哈佛医学院 小鼠gRNA AAV载体库 神经退行性疾病］

● Cell Reports.（IF=9.995）. Zhong C, et.al. (2022). A neural circuit from the dorsal CA3 to the dorsomedial hypothalamus mediates balance between risk exploration and defense. ［中国科学院深圳先进技术研究院 AAV9-CaMKII-eArchT-EYFP&AAV9-Ef1a-DIO-eArch3.0-EYFP 危险探索-防御行为］

● Journal of Neuroinflammation.（IF=9.578）.Fröhlich A, et.al. (2022). Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury. ［乌尔姆大学 AAV9-hSyn-TNFRSF11b-P2A-mCherry 创伤性脑损伤］

● Cell Rep.（IF=9.995）. Qi X, et.al. (2022). A nociceptive neuronal ensemble in the dorsomedial prefrontal cortex underlies pain chronicity. ［北京大学 AAV2/9-TRE3G-mCherry；AAV2/9-TRE3G-hM3DGq-mCherry 慢性疼痛］

● Nature. （IF=69.504）.Breton-Provencher, V. et al. (2022). Spatiotemporal dynamics of noradrenaline during learned behaviour. ［麻省理工学院 AAV9-hSyn-DIO-GRABNE2m 习得行为］

● Neurobiology of Stress.（IF=7.142）.Zhou H, et al. (2022). The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus. ［华中科技大学同济医学院 AAV-EF1a-DIO-hM3Dq-mCherry & AAV-EF1a-DIO-hM4Di-mCherry 抑郁症］

● CNS Neurosci Ther.（IF=7.035）.Yun Y, et al. (2022). Targeting upregulated RNA binding protein RCAN1.1: a promising strategy for neuroprotection in acute ischemic stroke. ［山东大学齐鲁医院 AAV9-R1SR13 & AAV9-R-CON；Lenti-RCAN1.1L-GFP & Lenti-siRCAN1.1-GFP & Lenti-R1SR13-GFP & Lenti-CON 急性缺血性卒中］

● Neuron.（IF=18.688）. Chi S, et.al. (2022). Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. ［清华大学 AAV2/9-GfaABC1D-ATP1.0 神经再生和认知］

● Cell Rep. （IF=9.995）.Dai B, et.al. (2022). Responses and functions of dopamine in nucleus accumbens core during social behaviors. ［纽约大学AAV9-hSyn-DIO-GRAB DA2m & AAV9-hSyn-loxP-GRAB DA2m -loxP 社会行为］

● Neurosci Bull.（IF=5.271）. Wang T, et.al. (2022). The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.［北京大学第六医院 AAV2/9-CAG-DIO-CRH-P2A-GFP 睡眠障碍］

● Mol Neurobiol.（IF=5.682）. Chen B, et.al. (2022). Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response. ［暨南大学 AAV9-CMV-GFP&scAAV1-hSyn-Cre 脊髓损伤］

● Neuropharmacology.（IF=5.273）. Wang T, et.al. (2022). Malfunction of astrocyte and cholinergic inputs is involved in postoperative impairment of hippocampal synaptic plasticity and cognitive function.［徐州医科大学 AAV-hSyn-GACh3.0 术后谵妄］

● Signal Transduction and Targeted Therapy.（IF=38.104）.Ling Zhang, et.al.（2021）.SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration.［中国医学科学院北京协和医学院 AAV2-CMV-GFP & AAV9-CMV-GFP 血脑屏障］

● Nat Microbiol.（IF=30.964）.Boqiang Sun, et.al.（2021）.Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus-1 latency.［浙江大学 AAV-CAG-Foxc1神经元］

● NATURE COMMUNICATIONS.（IF=17.694）.Qian Wang, et.al.（2021）.Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice ［南方医科大学AAV8-GFAP-hM3Dq-mCherry and AAV9-GfaABC1D-ATP1.0 自闭症］

● Molecular Neurodegeneration.（IF=18.879）.Melanie Barth, et.al.（2021） Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures［德国神经退行性疾病中心 AAV-hA53T-αS 小胶质细胞］

● Protein Cell.（IF=15.328）.Xiaoyan Xu, et.al.（2021）. Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model［浙江大学 AAV-CAG-Hsc70-WT & AAV-CAG-Hsc70 S85A阿尔兹海默症］

● Cell Reports.（IF=9.995）. Zhuo Chen，et.al.（2021）. Deficiency of ER Ca²⁺ sensor STIM1 in AgRP neurons confers protection against dietary obesity.［华中科技大学AAV-EF1a-DIO-EGFP AgRP神经元内质网Ca²⁺传感器］

● MOL THER-NUCL ACIDS. (IF=8.886). Qianqian Cao, et.al. (2022). Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology.［暨南大学 AAV9-hSyn-human SNCA 帕金森病］

● J Neuroinflammation. (IF=8.322). Huo S, et.al. (2021). Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice. ［南开大学 AAV9-CaMKIIα-TRPC5 & AAV9-GFP 记忆障碍］

● Nature Neuroscience. (IF=20.071). Zhang, G.W., et al. (2021). Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior. ［南加州大学 AAVretro-Cre 神经元逆行标记 焦虑与父母行为］

● Nature Communications. (IF=12.121). Xu, et.al. (2020). CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.［中国科学院昆明动物所 AAV9-shRNA(circGRIA1) & AAV9-shRNA(control) 灵长类动物恒河猴脑衰老］

● Science Advances. (IF=13.116). Sun, et.al. (2020). Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain.［北京大学 CRISPR-saCas9 基因编辑雄性SD大鼠特定神经元群］

● The Journal of Neuroscience. (IF=5.673). Zingg B, et.al. (2020). Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry.［南加利福尼亚大学scAAV1 hSyn-Cre & AAV1-hSyn-Flp & AAVretro-hSyn-Cre & AAV1-EF1a-DIO-Flp-WPRE & AAVretro-hSyn-GFP-WPRE 顺向跨单级突触示踪］

● Molecular Psychiatry. (IF=12.384). li, et.al. (2020). Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression.［山东大学 AAV9-CMV-mPdcd4-P2A-GFP 抑郁症］

● Biological Psychiatry. (IF=12.095). Zhang, et.al. (2020). Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability.［中国药科大学 Dox 诱导性AAV2/9-shRNA-Adcy5 or AAV2/9-shRNA 抑郁症］

● Cell Reports. (IF=8.109). Ma, et.al. (2019). Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation. ［北京大学 AAV2 retro-hSyn-Cre-GFP & AAV2-CAG-DIO-BDNF-mCherry-3*flag 慢性疼痛］

● Cell. (IF=38.637). Fan, et.al. (2019). Stress-Induced Metabolic Disorder in Peripheral CD4+T Cells Leads to Anxiety-like Behavior. ［浙江大学 AAV9-GFAP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(scramble) 焦虑精神疾病］

● Neuron. (IF=14.415). Feng, et.al. (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.［北京大学AAV9-hSyn-NE1m & NE1h and AAV9-hsyn-tTA 去甲肾上腺素神经递质探针］

● Cell. (IF=38.637). Sun, et.al. (2018). A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies,Fish, and Mice.［北京大学AAV-hSyn-DA1m & DA1h 多巴胺神经递质探针］

● Behavioural Neurology. (IF=2.093). Qu, et.al. (2018). MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice.［第三军医大学西南医院神经外科 MST1 AAV-4 in 1 shRNA-GFP 脑室注射 蛛网膜下腔出血］

● Neuron. (IF=14.415). Zingg B, et.al. (2017). AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors.［南加利福尼亚大学AAV1-EF1a-DIO-Flp 顺向跨单级突触示踪］

● Nature Communications (IF 14.7) Wang et.al. (2025). Serpina3k lactylation protects from cardiac ischemia reperfusion injury. [中国医学科学院阜外医院胡盛寿院士、周冰莹 AAV9-FSP1-SA3K-WT AAV9-FSP1-SA3K-K351R 心脏缺血损伤]

● Cardiovascular Diabetology (IF=8.5).Wang R, et.al. (2024). Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway.［暨南大学第一附属医院 AAV9-FGF21、AAV9-GFP；AAV9-shFGF21、AAV9-Con  糖尿病心肌病］

● Cardiovascular Research. (IF=10.2) Che et.al. (2024). Cardiac tumour necrosis factor receptor-associated factor 7 mediates the ubiquitination of apoptosis signal-regulating kinase 1 and aggravates cardiac hypertrophy. [武汉大学人民医院唐其柱团队 AAV9-cTNT-Traf7、AAV9-cTNT-GFP 心脏肥大]

● Experimental & Molecular Medicine（IF 9.5）.Xian GP.（2024）. Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.［南方医科大学 , AAV2-circHIPK3、AAV2-vector，主动脉瓣钙化病］

● Cell Death and Disease（IF 8.1）.Zhen J.（2024）. Histone acetyltransferase Kat2a regulates ferroptosis via enhancing Tfrc and Hmox1 expression in diabetic cardiomyopathy.［吉林大学第一医院尉海涛，AAV9-Alkbh5，AAV9-shAlkbh5；AAV9-Hmox1，AAV9-shHmox1；AAV9-Ythdf2，AAV-shYthdf2；AAV9-Kat2a，AAV9-shKat2a；AAV9-Trfc， AAV9-shTrfc；AAV9-GFP，AAV9-shNC，糖尿病心肌病］

● Signal Transduction and Targeted Therapy (IF 40.8). Chen et.al. (2024). PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis. [中国医学科学院胡盛寿/李向杰/宋江平 心肌纤维化]

● Molecular Therapy (IF 12.4). Xie et.al. (2024). Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts. [华中科技大学同济医学院附属同济医院，AAV9-cTNT-AGO2 NLS，AAV9-cTNT-AGO2 NES，AAV9-cTNT-shAGO2，AAV9-cTNT-shANKRD1，心力衰竭]

● Advanced Science (IF 15.1). Guo et.al. (2023). NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R. [山东大学齐鲁医院，AAV9-FSP1-NKRF、AAV9-FSP1-HuR、AAV9-FSP1-shHuR、Ad-NKRF，Ad-HuR 心肌梗死]

● Adv. Sci.（IF 15.1）.Cao XY.（2024）. Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis.［香港中文大学，AAV8-HCRApoE-hAAT-mPCSK9，尾静脉注射，2.5×10^11 vg/mouse.动脉粥样硬化造模］

● Acta Pharmaceutica Sinica B（IF 14.5）. Yu W, et.al. (2023). Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis.［中山大学药学院 AAV9-shTFRC、AAV9-shNC 三到五点心肌注射 心肌病］

● Free Radical Biology and Medicine. (IF 7.4). Zhang et.al. (2023). Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis. [第四军医大学基础医学院、第四军医大学西京医院，AAV和腺病毒过表达载体AAV9-cTNT-frataxin，Ad-Frataxin 心脏]

● Journal of Molecular Medicine，（IF 5.606）. Shao SY.（2023）. Never in mitosis gene Arelated kinase6 deficiency deterioratesdiabetic cardiomyopathy via regulating heat shock protein 72.［郑州大学第一附属医院Ad-NEK6，MOI=50，心肌细胞，糖尿病心肌病］

● Journal of Molecular Medicine. (IF=5.606). Wu L, et.al. (2023). TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis.［郑州大学第一附属医院AAV9-cTnT-TRIM44、AAV9-cTnT-shTRIM44 心肌肥厚］

● Oxidative Medicine and Cellular Longevity. (IF=7.310). Li WJ, et.al. (2023). Cryptotanshinone Attenuated Pathological Cardiac Remodeling In Vivo and In Vitro Experiments. ［武汉大学人民医院AAV9-STAT3 & AAV9-GFP 心脏重塑］

● Cell Reports. (IF=8.8). Zou J, et.al. (2023). Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation. ［奥古斯塔大学AAV9-cTnT-Cre-WPRE 心脏成熟］

● Cells. (IF=7.666) Fangfang Li et.al. (2022). KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling. [徐州医科大学附属医院 KLF9 AAV过表达和干扰载体 糖尿病性心肌病]

● cells.（IF=7.666）. Chen Z, et.al. (2022). TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice. ［华中科技大学同济医学院武汉中心医院 AAV9-cTNT-TMEM43；AAV9-cTNT-shTMEM43 脓毒症性心肌病］

● Sci Adv. (IF=14.136). Bi HL, et.al. (2022). The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. ［大连医科大学附属医院 rAAV9-CMV-UCHL1 & rAAV9-CMV-GFP 心肌肥厚］

● ACTA PHARM SIN B. （IF=14.903）. Wu X, et al. (2022). Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS. ［中国药科大学 AAV9-cTnT-shPKM2 & AAV9-cTnT-wildtype PKM2 & AAV9-cTnT-mutants PKM2 心肌缺血］

● Mol Ther. (IF=12.910). Zheng H, et al. (2022) . CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. ［南方医科大学 AAV9-circSamd4&AAV9-NC 心肌梗死］

● FRONT CARDIOVASC MED. (IF=7.419).Xin Huang , et.al. (2021). Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology.［首都医科大学 AAV9-Sfrp5心肌梗死］

● MOL THER-NUCL ACIDS. (IF=8.886). Xiang He, et.al. (2021). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. ［南方医科大学南方医院 AAV9-circChordc1-shRNA & AAV9-Scr 腹主动脉瘤］

● Theranostics. (IF=11.556). Hao Li, et.al. (2021). Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)–induced dissecting abdominal aortic aneurysm . ［中国医学科学院阜外医院 AAV9-LH1-P2A-GFP & AAV9-GFP 腹主动脉瘤］

● J Mol Med (Berl). (IF=4.599). Li F, et.al. (2021). Zinc finger and BTB domain-containing protein 20 aggravates angiotensin II-induced cardiac remodeling via the EGFR-AKT pathway. ［徐州医科大学附属医院 AAV9-ZBTB20 & AAV9-shZBTB20 心脏重构］

● Hypertension. (IF=7.713). Liu, Wen, Li, et.al. (2020). Oleic Acid Attenuates Ang II（Angiotensin II）-Induced Cardiac Remodeling by Inhibiting FGF23（Fibroblast Growth Factor 23.［中国医学科学院阜外医院 AAV9-Fgf23&AAV9-GFP 高血压心脏重构］

● International Journal of Molecular Medicine. (IF=3.098). Huang, et.al. (2019). Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy.［华中科技大学同济医学院附属协和医院 AAV9-Redd1 & AAV9-GFP 心肌梗死MI］

● Frontiers in Pharmacology. (IF=4.225). Shen, et.al. (2019). Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib.［河北医科大学 AAV9-cTNT-GFP-miR-146a & AV-miR-146a SNT-诱导的心脏收缩障碍］

● Journal of Molecular and Cellular Cardiology. (IF=4.133). Wu, et.al. (2019). The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling.［武汉大学 AAVs & Ads心脏重构］

● Biochemical and Biophysical Research Communications. (IF=2.985). Yang, et.al. (2018). Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic flux and restoring lysosomal function.［山东大学齐鲁医院 AAV-vaspin & Ad-RFP-GFP-LC3 心脏］

● Advanced Science (IF=14.3). Cui X, et.al. (2024). ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure.［山东大学齐鲁医院&哈尔滨医科大学附属第二医院 AAV9-SM22α-shRGS2；AAV9-SM22α-shZFP36；AAV9-CTR shRNA  高血压］

● Nature Communications (IF=14.7) .Liu Y, et.al. (2025). E3 ubiquitin ligase RNF128 promotes Lys63-linked polyubiquitination on SRB1 in macrophages and aggravates atherosclerosis.［山大齐鲁医院&山大基础医学院 AAV-PCSK9  动脉粥样硬化］

● Metabolism (IF 10.8)  Liu et.al. (2024). Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I. [天津医科大学付成来、朱毅AAV-mPCSK9  心血管]

● Acta Pharmacologica Sinica ( IF 6.9 ). Zheng et.al. (2024). Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol. [暨南大学药学院刘志平团队、中山大学药学院刘培庆团队 血管内皮细胞衰老]

● Phytomedicine （IF 7.9）. Zou J, et.al. (2024). Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm.［暨南大学&广东医科大学 AAV2-SM22α-shNrf2、AAV2-sh-control 腹主动脉瘤］

● BMC Medicine (IF 9.3). Sheng Y, et.al. (2023). Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection.［广州市第一人民医院、中国医学科学院阜外医院 AAV9-U6-shNinj1、AAV9-NC 眶后静脉注射 胸主动脉夹层］

● Cell Death & Disease. (IF 9.0). Deng et.al. (2023). Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6. [山东大学齐鲁医院，AAV干扰载体、AAV-PCSK9 动脉粥样硬化]

● Autophagy. (IF=13.391). Chen Z, et.al. (2022). Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy. ［中国医学科学院阜外医院 rAAV8-HCRApoE/hAAT-D377Y-mPCSK9 动脉粥样硬化］

● Theranostics. (IF=11.600) .Hao Li, et.al.（2021）. Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)–induced dissecting abdominal aortic aneurysm. [北京协和医科大学AAV9-LH1&AAV9-GFP 腹主动脉瘤]

● Molecular Therapy: Nucleic Acids. (IF=10.183).Xiang He，et.al.(2021). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. [南方医科大学 AAV-circChrodc1-shRNA 腹主动脉瘤]

● Biomed Pharmacother. (IF=6.529). Wu Y, et.al. (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice. ［香港中文大学 AAV-Vector & AAV-ICAM2-Ppard 下肢缺血］

● J ADV RES. (IF=10.479). Chak Kwong Cheng, et.al. (2022). SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. ［香港中文大学 AAV-Vector & AAV-ICAM2-SOX4 动脉粥样硬化］

● Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhao, et.al. (2019). ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.［山东大学齐鲁医院 AAV2-SM22α-ALDH2 & AAV1-ICAM2-ALDH2 低氧性肺动脉高压HPH］

● Journal of Molecular and Cellular Cardiology. (IF=4.133). Sun, et.al. (2019). LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA.［南方医科大学南方医院 AAV9-H19 腹主动脉瘤AAA］

● Journal of Cerebral Blood Flow & Metabolism. (IF=5.681). Li, et.al. (2019). Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice.［中国医学科学院阜外医院 AAV9-LH3-p2A-GFP 高血压性脑出血ICH］

● Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhong, et.al. (2019). SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB).［南方医科大学南方医院 AAV9-SM22α 腹主动脉瘤AAA］

●Acta Pharmaceutica Sinica B (IF 14.7) Guo et.al. (2025). Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1dependent epigenetic modulation of NADPH oxidase 4. [山东大学齐鲁医学院顾俊莲 AAV8-TBG-CTL、AAV8-TBG-shNox4、AAV8-TBG-Sirt1 肝脏]

●Cell Reports (IF=7.5).Xue C, et.al. (2024). Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.［中国科学技术大学/北京协和医学院/合肥工业大学 AAV8-TBG-EGFP-miR30-shNogo-B、AAV8-TBG-EGFP-miR30-shControl 胆固醇代谢］

●Nature Communications (IF=14.7).Yang X, et.al. (2024). FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury.［浙江大学转化医学研究院/浙江省人民医院 AAV8-TBG-Alox15 shRNA 肝移植损伤］

●Journal of Hematology & Oncology (IF 29.5). Wang et.al. (2024). METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma. [上海东方医院高勇/李砚东团队 AAV8-TBG-Cre 肝细胞癌]

●Signal Transduction and Targeted Therapy（IF 40.8）.Yan H.（2024）. Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis.［北大基础医学院，北大人民医院,吉林大学,吉林大学第一医院,AAV8-RIMKLA，AAV8-GFP，非酒精性脂肪性肝病］

●Military Medical Research (IF 16.7).Hu CQ, et.al. (2024). PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis.［北大基础医学院/北大人民医院/吉林大学第一医院 AAV8-CMV-FAM3A、AAV8-CMV-GFP 肝脏糖脂代谢］

●Cell Reports Medicine（IF 14.3）.Zhu WZ.（2024）. Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.［上海中医药大学、湖州市中心医院，AAV8-TBG-A1R，AAV8-TBG-GFP，尾静脉注射，10^12vg per mice，肝脏MASH］

●Cell Death & Disease (IF 9.0). Li et.al. (2023). Gp78 deficiency in hepatocytes alleviates hepatic ischemiareperfusion injury via suppressing ACSL4-mediated ferroptosis. [浙江大学医学院徐骁/刘治坤/王迪团队，AAV8-TBG-gp78，肝脏］

●Journal of Lipid Research.（IF=6.5）.Yang Z, et.al. (2024). Histone demethylase KDM1A promotes hepatic steatosis and inflammation by increasing chromatin accessibility in NAFLD.［武汉大学人民医院、赣南医科大学 AAV8-sgKDM1A 非酒精性脂肪肝］

●Redox Biology（IF 11.4）.Yuan JT.（2024）. DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.［中国科学院大学、北京朝阳医院、美国密西西比大学，AAV8-TBG-Prdx1，AAV8-TBG-GFP . 尾静脉注射，1.1×10^12 vg/mouse］

●Journal of Translational Medicine. (IF=7.4).Yang L, et.al. (2024). ANGPTL3 is a novel HDL component that regulates HDL function.［首都医科大学附属北京潞河医院 AAV2/8-ANGPTL3、AAV2/8-vector、AAV2/8-shANGPTL3、AAV2/8-shNC  2型糖尿病］

●Acta Pharmaceutica Sinica B (IF=14.5). Huang ZF, et.al. (2023). FGF4 protects the liver from immune-mediated injury by activating CaMKKb-PINK1 signal pathway to inhibit hepatocellular apoptosis.［温州医科大学附属第一医院 AAV8-TBG-shFGFR4、AAV8-TBG-shPINK1 免疫性肝损伤］

●Cell Death & Disease (IF=9.685). Tao X, et.al. (2023). Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk.［华中科技大学同济医学院附属同济医院 AAV8-TBG-PDE4D、AAV8-GFP； 非酒精性脂肪性肝病］

●ACTA PHARM SIN B（IF=14.903）.Shen X, et.al. (2023). Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice:Involvement of reduced S100A11 expression.［中国科学院大学AAV8-TBG-hDDAH1、AAV8-His；AAV8-shS100a11、AAV8-GFP； 非酒精性脂肪性肝病］

●International Journal of Molecular Sciences. (IF 6.208). Chen et.al. (2023). Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway. [山东大学齐鲁医院 AAV过表达载体 AAV-TBG-FBXO2 肝脏]

●Molecular Therapy: Nucleic Acid（IF 8.8）. Yang XS.（2023）.PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit 1 progression of hepatocellular carcinoma［中国医学科学院 AAV8-PPM1H，AAV8-control 尾静脉注射，肝脏］

● Acta Pharmaceutica Sinica B. (IF 14.903). Zhu et.al. (2023). The E3 ubiquitin ligase NEDD4-1 protects against acetaminopheninduced liver injury by targeting VDAC1 for degradation. [吉林大学动物医学院 AAV过表达和干扰载体 肝脏]

● Nature Communications. (IF 17.694) Xiao et.al. (2023). Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [复旦大学脑科学转化研究院 PREP AAV过表达载体 肝脏和脂肪产热］

● Cell Biol Toxicol（IF=6.819）.Chen X, et.al. (2022). Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress. ［中国药科大学AAV8-siSTING & AAV8-control 肝毒性］

● Metabolism（IF=13.934）.Yan H, et.al. (2022). FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP Synthase.［北京大学医学部基础医学院AAV8-U6-shFOXD3 &AAV8-U6-GFP（pAV-3in1-shRNA-GFP ）  代谢性疾病］

● Hepatology. (IF=17.298). Wang T, et.al. (2022). Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression. ［华中科技大学同济医学院&西安交通大学 AAV8-CRISPR/sgZmiz1 &AAV8-CRISPR/sgYbx1 肝内胆管细胞癌］

● Cell Metabolism.(IF=31.373) . Lin Wang, et.al.（2021）. Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.［第四军医大学西京医院肝胆外科 AAV8-TRIM16 & AAV8-GFP 非酒精性脂肪性肝炎］

● Cell Metab. (IF=27.287). Wang L, et.al. (2021). Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1. ［第四军医大学西京医院 AAV8-CMV-TRIM16&AAV8-CMV-GFP 非酒精性脂肪性肝炎］

● Hum Cell. (IF=4.174). Chen S, et.al. (2021). Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination. ［杭州医学院附属人民医院 AAV8-TBG-RNF20 肝纤维化］

● Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). Zhang, et.al. (2020). Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.［中国人民解放军军事医学科学院 & 南开大学 AAV-DJ-CAG-Cre II型戊二酸尿症GA-II］

● Journal of Hepatology. (IF=20.582). She, et.al. (2019). PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.［北京大学基础医学院 AAV8-hPSMP & null 肝纤维化］

● Theranostics. (IF=8.579). Liu, et.al. (2019). Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration.［浙江大学 AAV9-CMV-YAP 肝再生］

● Molecular Cell. (IF=15.584). Wan, et.al. (2019). Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.［浙江大学 AAV9-mCherry-GFP-LC3 and AAV9-Pacerwt-HA&Pacer2KR-HA&PacerS157A-HA&PacerS157D-HA 肝自噬和脂代谢］

● Experimental Cell Research. (IF=3.383). Li, et.al. (2018). Brg1 promotes liver fibrosis via activation of hepatic stellate cells.［华中科技大学同济医学院附属同济医院 AAV8-shBrg1 or AAV8-GFP 肝纤维化］

● Molecular Cell. (IF=15.584). Wan, et.al. (2018). mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.［浙江大学 AAV9-shHUWE1 & shNC and AAV9-WIPI2&WIPI2-S395A&WIPI2-S395D 肝自噬］

● Molecular Cell. (IF=15.584). Su, et.al. (2017). VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy.［浙江大学 AAV9-CMV-VPS34&3KR&3KQ 肝自噬］

● Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). He, et.al. (2017). MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor.［第二军医大学 AAV8-CMV-eGFP-miR-351-5p Sponge 血吸虫病肝纤维化］

● Cell Reports (IF 8.8). Nan et.al. (2023). m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation. [中国医学科学院刘芝华/李印团队，AAV-shLINK-A，AAV-shCtrl，食管癌]

● MOLECULAR THERAPY.（IF=12.910）. Nan Y, et.al. (2022). HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity.［中国医学科学院肿瘤医院 AAV-shHCP5 & AAV-shCtrl 食管鳞癌］

● Cell Death & Disease (IF 9.0).Li YT, et.al. (2023). Targeting LGSN restores sensitivity to chemotherapy in gastric cancer stem cells by triggering pyroptosis.［深圳大学医学部 AAV9-shLGSN、AAV9-shNTC 胃癌］

● Cell Death & Disease (IF=8.1). Shao L, et.al. (2024). FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes.［深圳大学医学部 AAV9-CMV-SaCas9-3xHA-U6-sgCox6a2、AAV9-vector 2型糖尿病］

● Nature Communications（IF 16.6）.Zhang H.（2024）. ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.［中南大学湘雅二医院、华中科技大学同济医学院附属协和医院，AAV8-shZDHHC20，AAV8-shControl ，腹腔注射100 μL/mouse，胰腺癌］

● Acta Pharmaceutica Sinica B（IF 14.5）. Liu Y, et.al. (2023). A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.［中国药科大学 AAV-shGSDME、AAV-shC 瘤内注射 胰腺导管腺癌］

● Cellular and Molecular Life Sciences，（IF 9.207）. Zhao Xingqi.（2023）. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.［南京师范大学，AAV8-SYT7 & AAV8-null，胰腺导管内注射］

● ISCIENCE. (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells. [中山大学附属第一医院 AAV和腺病毒过表达载体 胰腺]

● Digestive Diseases and Sciences .（IF=3.487）.XiaoYu Yang，et.al.（2021）.MiR155 Disrupts the Intestinal Barrier by Inducing Intestinal Inflammation and Altering the Intestinal Microecology in Severe Acute Pancreatitis.［南昌大学第一附属医院AAV9-miR155和AAV9-miR155 sponge胰腺炎］

● Nature Communications（IF17.694）.Cheng R, et.al. (2023). Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity.［中国药科大学&东南大学AAV8-MIP (mouse insulin1 promoter)-circGlis3 糖尿病］

● Cell Research.（IF=46.297）.Cheng R, et.al. (2022). A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.［中山大学第一附院&苏州大学&南京大学AAV9-shRNA-RASON&AAV9-shRNA-NC  KRAS突变癌］

● Clinical Cancer Research. (IF13.801). Ding et.al. (2023). A Tumor-suppressive Molecular Axis EP300/circRERE/ miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer. [厦门大学第一附属医院 AAV-CMV-circRNA-mCMV-copGFP AAV过表达载体 癌症]

● J Immunother Cancer .（IF=12.461）.Chao Liu，et.al.（2021）.Blocking IL- 17A enhances tumor response to anti- PD-1 immunotherapy in microsatellite stable colorectal cancer.［哈尔滨医科大学附属肿瘤医院AAV-miR-15b-5p sponge结直肠癌］

● Cancer Lett.（IF=9.756）.SiMiao Qiao，et.al.（2020）.Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer.［中国药科大学AAV9-CPT1 & AAV9-control 结直肠炎］

● Nature Cell Biology (IF 17.3) Chen et.al. (2025). Rpl12 is a conserved ribophagy receptor. [浙江大学易聪、邹炜团队，广州医科大学冯杜团队、国科大杭州高等研究院黄云鹏团队联合天津大学梅坤荣 rAAV9-RPL12-WT、rAAV9-RPL12 P3N-E21L 核糖体稳态]

● Nature Metabolism (IF 18.9). Zheng et.al. (2024). S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes. [浙江大学医学院附属第四医院Dante Neculai、刘伟团队联合加拿大多伦多大学Brian Raught团队和加拿大戴尔豪斯大学Gregory D. Fairn团队 脂肪代谢]

● Circulation，（IF 37.8）.Zhan JB .（2023）. Ago2 protects against diabetic cardiomyopathy via activating mitochondrial gene translation.［华中科技大学附属同济医院心血管内科，AAV9-cTNT-NLS-Ago2，AAV9-cTNT-NES-Ago2，AAV9-cTNT-COX8-Ago2，AAV9-cTNT-shRNA-Ago2，尾静脉注射，糖尿病］

●Metabolism，（IF 9.8）.Hu YT.（2023）. Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.［北京大学医学部基础医学院、北京大学人民医院，AAV8-FPR1、AAV8-GFP，尾静脉注射，肝脂肪代谢］

● Nature Communications. (IF 17.694). Zhong et.al. (2023). Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice. [中山大学附属第六医院 AAV8-TAK1；AAV8-Vec；AAV8-Adipoq-Cre AAV过表达载体肥胖代谢]

● Acta Pharmaceutica Sinica B.（IF=14.5）.Tang WZ，et.al.（2023）.Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice.［南方科技大学&南方科技大学第一附属医院 AAV-Rec2-CasRx-sgRNA-Kindlin-2 脂肪］

● Protein & Cell.（IF=15.328）.Maomao-Pu，et.al.（2023）.ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover .［浙江大学医学院 AAV9-ORP8-WT 、AAV9-ORP8-T54A/S65A、AAV9-ORP8-LIRs-6A 、AAV9- ORP5 脂滴自噬］

● Cell Death and Differentiation (IF=13.7) .Liu C, et.al. (2024). Foxk1 promotes bone formation through inducing aerobic glycolysis.［深圳市人民医院  AAV9-Osterix-Foxk1、AAV9-Osterix-GFP  骨形成］

● Cell Communication and Signaling (IF 8.2).Sun K, et.al. (2024). IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.［华中科技大学同济医学院附属同济医院 AAV9-shZBP1、AAV9-shGFP 骨关节炎］

● Free Radical Biology and Medicine.（IF=8.101）.Kai Sun，et.al.（2023）.JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.［华中科技大学同济医学院附属同济医院关节腔内注射AAV9-NCOA4 & AAV9-GFP骨关节炎治疗］

● Nature Metabolism (IF 18.9) Peng et.al. (2025). Cellular Feimin enhances exercise performance by suppressing muscle thermogenesis. [清华大学王一国 AAV9-cFeimin；AAV9-cFeimin 112/128T/A；AAV9-cFeimin 112/128T/D；AAV9-cFeimin 124/140R/D；AAV9-shcFeimin  肌肉产热]

● Molecular Therapy (IF=12.4). Cataldi MP, et.al. (2023). Improved efficacy of FKRP AAV gene therapy by combination with ribitol treatment for LGMD2I.［Atrium Health卡罗来纳医疗中心 AAV9-MCK-FKRP  肌营养不良］

● Science Advances（IF=13.6）. Jia M, et.al. (2023). ULK1-mediatedmetabolic reprogramming regulates Vps34 lipid kinase activity by itslactylation.［华东理工大学 rAAV-Vps34WT、rAAV-Vps342KR、rAAV-Ctrl  骨骼肌稳态］

● Skeletal Muscle (IF=4.9).Witcher PC, et.al. (2023). Expression of Myomaker and Myomerger in myofbers causes muscle pathology.［辛辛那提儿童医院 AAV9-CMV-Myomerger 、AAV9-GFP  肌肉病理］

● Biomedicine & Pharmacotherapy（IF=7.5 ）.Wu Y, et.al. (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice.［香港中文大学 AAV1-ICAM2-Ppard 、AAV1-control  糖尿病血管病变］

● JCI Insight (IF=8.0).Kwong JQ, et.al. (2018). The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.［辛辛那提儿童医院 AAV9-Cre、 AAV9-GFP  骨骼肌代谢］

● Redox Biology，（IF 10.787）. Zhu Jian.（2023）. The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3 .［海军军医大学第二附属医院（上海长征医院），AAV-USP11 & AAV-Ctrl，椎间盘内注射］

● Cell Reports.（IF=9.995）. Liu, et.al. (2022). Template-independent genome editing in the Pcdh15 av-3j mouse, a model of human DFNB23 nonsyndromic deafness.［清华大学 AAV2/9-mCherry&AAV2/9-m-3j-gRNA1 遗传性耳聋］

● Cell Reports Medicine (IF 14.3).Li CP, et.al. (2024). Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma.［中国科学院动物研究所、北京同仁医院 AAV2-CAG-PLAP、AAV2-CAG-CNTF 青光眼神经退行性病变］

● Cell Death and Disease，（IF 9）.Li Y.（2023）. TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy.［南京医科大学附属无锡人民医院，AAV8-shTGR5，AAV8-vector，玻璃体内注射2μL，糖尿病视网膜病变］

● Antioxidants(IF7.675).ZhangF,et.al.(2023).Melatonin Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting p53–Mediated Ferroptosis.［中山大学中山眼科中心 AAV2-p53& AAV2-GFP 视网膜缺血再灌注］

● COMPUT STRUCT BIOTEC（IF 6.155）. Zhang J, et.al. (2023). PDGF-D-induced immunoproteasome activation and cell-cell interactions.［中山大学中山眼科中心&广医-广州生物院 AAV-VMD2-PDGF-D&AAV-GFP 脉络膜新生血管］

● International Journal of Biological Sciences. (IF=4.858). Wu, et.al. (2019). Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.［温州医科大学附属第二医院 AAV9-U6-shRNA (Prkaa1)-CMV-EGFP 随意皮瓣］

● Molecular Therapy (IF 12.1).Song Z, et.al. (2024). The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2.［北大基础医学院、北大第一医院 AAV9-hPSMP、AAV9-null 急性肾损伤］

● Metabolism Clinical and Experimental，（IF 9.8）. Zuo Fuwen.（2023）. CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease.［山东大学基础医学院，AAV9-Nphs1-Ccdc92、AAV9-Nphs1-shAbca1，糖尿病肾病-肾实质内注射］

● Cell Death Discovery. (IF 7.0). Zhang et.al. (2023). Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis. [南京医科大学第一附属医院 AAV慢病毒过表达载体 AAV9-RCAN1.4 LV-RCAN1.4、LV-YY1  肾脏]

● Life Sciences（IF=6.780）. Hu BC, et.al. (2023). Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage.［浙江省人民医院AAV9-KSP1.3-miR30-sh.NIX &AAV9-sh.scr 脓毒性AKI］

● Nature Communications (IF=17.694). Yang Y, et.al. (2023). DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice.［南京医科大学附属儿童医院AAV8-U6-gRNA-DNA-PKcs；AAV8-U6-gRNA 慢性肾脏病］

● Molecular Therapy. （IF=12.910）. Ouyang X, et.al. (2022). A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating AKT/mTOR-autophagy pathway. ［广东人民医院 AAV9-sh-circ-ZNF609 & AAV9-ZNF609-250 & AAV9-sh-NC 急性肾损伤］

● Cytokine.(IF=3.926). Xu H, Wang Z. (2022). MicroRNA-23a-3p ameliorates acute kidney injury by targeting FKBP5 and NF-κB signaling in sepsis.［江西省人民医院 AAV2-miR-23a-3p 脓毒症急性肾损伤］

● Molecular Therapy. (IF=12.910) . Sung-Ah Hong, et.al.（2021）. In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment. [延世大学AAV9-HITI & AAV9-SaCas9-sgRNA & AAV9-EGFP 肾上腺脑白质营养不良(ALD)]

● Acta Pharm Sin B. (IF=11.413). Jing X, et.al. (2021). Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury. ［山东大学 rAAV9-Fgr-GFP & rAAV9-GFP 急性肾损伤］

● J Pharmacol Sci. (IF=3.337). Zhou J, et.al. (2021). Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis. ［南京中医药大学附属医院 AAV9-miR-499-5p & AAV9-APC 糖尿病肾病］

● EBIOMEDICINE. (IF=5.736). Liu, et.al. (2019). H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway.［华中科技大学同济医学院附属同济医院 AAV9-H19 肾钙质沉着症］

● Science Translational Medicine. (IF=16.304). Wang, et.al. (2018). Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway.［南方医科大学 AAV9-MIR-GFP-lnc-TSI 肾纤维化］

● Allergy (IF 12.4).Jia M, et.al. (2023). DEL-1, as an anti-neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma.［南京医科大学第一附属医院 AAV6-DEL-1 鼻吸 支气管哮喘］

● Microbiology Spectrum（IF=9.043）.Zhang Z, et.al. (2023). Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p–CUEDC2 Axis.［浙江大学动物医学中心 AAV6-lnc-AROD & AAV6-NC 宿主先天防御］

● Cell Death & Disease. (IF=6.304). Zhang, et.al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.［上海市第一人民医院 AAV6-circHIPK3 shRNA & scrambled shRNA 肺纤维化］

● Oncotarget. Tian, et.al. (2017). Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling.［华中科技大学同济医学院公共卫生学院 AAV-Sirt6 特发性肺纤维化］

● Retrovirology. (IF=4.183). Wang, et.al. (2017). Genome modifcation of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection.［武汉大学基础医学院 AAV-SaCas9-CXCR4-gRNA HIV基因治疗］

● Cell Metab. (IF=27.287). Loft Anne, et.al. (2022). A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.［德国慕尼黑赫尔姆霍茨中心&乌尔姆大学 AAV-LP1-Cre & AAV-LP1-Cremut 肝脏禁食与生酮反应］

● EBioMedicine. (IF=8.143). Song Haoyu, Xu Tong, Feng Xiaofei, et.al. (2020). Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.［南方医科大学&暨南大学附属珠海医院 AAV2-Irg1-GFP & AAV2-Nrf2-GFP& AAV2-Keap1-GFP 腹主动脉瘤AAA］

● EBioMedicine. (IF=5.736). Lian, et.al. (2019). Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway. ［北京大学 AAV2-ADAM17-GFP & AAV2-GFP 主动脉夹层AD］

● Circulation Research. (IF=14.467). Fu, et.al. (2016). Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Defciency Drives Atherosclerotic Calcifcation. ［北京大学 AAV2-integrin β3 & AAV2-β-tail domain & AAV2-GFP 动脉粥样硬化AS］

● Leukemia (IF 11.4). Jiang J, et.al. (2023). Inserting EF1α-driven CD7-specific CAR at CD7 locus reduces fratricide and enhances tumor rejection.［浙大医学院 AAV-CD7 CAR  CAR-T细胞疗法］

● CLINICAL CANCER RESEARCH（IF=13.801）.Zhang Y, et.al. (2023). Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer.［Allogene公司 AAV-IL7 & AAV-IL15 小细胞肺癌］

● Mol Ther. (IF=12.910). Duan Y, et.al. (2022). Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency. ［浙江大学医学院AAV-TRAC-1928z-WT & AAV-TRAC-1928z-1XX CAR-T细胞制备］

● Small Methods. (IF=15.367).Ruirui Jing，et.al.（2021）.Cas9-Cleavage Sequences in Size-Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T Cells ［浙江大学AAV-TRAC-CAR-T ］

● Molecular Cell.(IF=17.970).Ling, et.al.(2021). Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates.［北京大学AAV6-CD19 CAR CAR-T细胞制备］

● Molecular Therapy: Nucleic Acid（IF=10.183）.Iancu O, et.al. (2022). Multiplex HDR for Disease and Correction Modeling of SCID by CRISPR Genome Editing in Human HSPCs.［巴伊兰大学  AAV6病毒产品 严重联合免疫缺陷］

● Journal of Extracellular Vesicles. (IF 16). Huang et.al. (2023). Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis. [中山大学附属第三医院，AAV干扰载体、腹膜纤维化]

●CELL PROLIFERATION (IF 5.9).Zhang S, et.al. (2024). AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure.［中山大学 AAV8-CAG-Lhcgr、AAVDJ-CAG-Lhcgr 雄性不育］

●BMC Biology（IF=7.364）. Ying Z, et.al. (2022). CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72.［深圳大学 HCR-KO HeLa细胞系 中心体组装］

●Cellular & Molecular Immunology. (IF 22.096). Lv et.al. (2023). Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells. [吉林大学第一医院表达ICOSL的细胞系 免疫]